Generic Name: thiothixene (THYE oh THIX een)
Brand Names: Navane
What is Navane (thiothixene)?
Thiothixene is an antipsychotic medication. It affects the actions of chemicals in your brain.
Thiothixene is used to treat schizophrenia.
Thiothixene may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Navane (thiothixene)?
Thiothixene is not for use in psychotic conditions related to dementia. Thiothixene may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
You should not use this medication if you are allergic to thiothixene, or if you have a blood cell disorder such as anemia or low white blood cells or platelets, or if you have decreased alertness caused by taking certain medications or drinking alcohol.
Call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.
Thiothixene may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not drink alcohol. Thiothixene can increase the effects of alcohol, which could be dangerous.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Thiothixene can decrease perspiration and you may be more prone to heat stroke.
What should I discuss with my healthcare provider before taking Navane (thiothixene)?
Thiothixene is not for use in psychotic conditions related to dementia. Thiothixene may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use thiothixene if you are allergic to it, or if you have:
a blood cell disorder such as anemia, low white blood cell counts, or low platelets; or
drowsiness, slow breathing, weak pulse, or decreased alertness caused by taking certain medications or drinking alcohol.
To make sure you can safely take thiothixene, tell your doctor if you have any of these other conditions:
epilepsy or other seizure disorder;
heart disease;
a history of low white blood cell (WBC) counts;
a history of breast cancer; or
if you are addicted to alcohol.
Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking thiothixene, do not stop taking it without your doctor's advice. It is not known whether thiothixene passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Thiothixene should not be given to a child younger than 12 years old.
How should I take Navane (thiothixene)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
You may not start feeling better right away when you start taking thiothixene. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment.
You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include drowsiness, dizziness, muscle stiffness or twitching, increased salivation, trouble swallowing, weakness, loss of balance or coordination, and fainting.
What should I avoid while taking Navane (thiothixene)?
Thiothixene may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not drink alcohol. Thiothixene can increase the effects of alcohol, which could be dangerous.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Thiothixene can decrease perspiration and you may be more prone to heat stroke.
Avoid exposure to sunlight or tanning beds. Thiothixene can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Navane (thiothixene) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking thiothixene and call your doctor at once if you have a serious side effect such as:
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking);
trouble swallowing;
vision changes;
swelling in your hands or feet;
seizure (convulsions);
pale skin, easy bruising or bleeding, unusual weakness; or
fever, chills, body aches, flu symptoms.
Less serious side effects may include:
dizziness or drowsiness;
feeling restless or agitated;
sleep problems (insomnia);
breast swelling or discharge;
changes in your menstrual periods;
nausea, vomiting, diarrhea, constipation;
changes in weight or appetite;
dry mouth, increased thirst; or
impotence, loss of interest in sex.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Navane (thiothixene)?
Before using thiothixene, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). You should not take thiothixene if you have drowsiness caused by other medications.
Tell your doctor about all other medications you use, especially:
carbamazepine (Carbatrol, Tegretol);
blood pressure medications;
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
glycopyrrolate (Robinul);
mepenzolate (Cantil);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare); or
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).
This list is not complete and other drugs may interact with thiothixene. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Navane resources
- Navane Side Effects (in more detail)
- Navane Use in Pregnancy & Breastfeeding
- Drug Images
- Navane Drug Interactions
- Navane Support Group
- 3 Reviews for Navane - Add your own review/rating
- Navane Prescribing Information (FDA)
- Navane MedFacts Consumer Leaflet (Wolters Kluwer)
- Navane Monograph (AHFS DI)
- Navane Advanced Consumer (Micromedex) - Includes Dosage Information
- Thiothixene Prescribing Information (FDA)
- Thiothixene Professional Patient Advice (Wolters Kluwer)
- thiothixene Advanced Consumer (Micromedex) - Includes Dosage Information
Compare Navane with other medications
- Psychosis
Where can I get more information?
- Your pharmacist can provide more information about thiothixene.
See also: Navane side effects (in more detail)
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